Research progress on cognitive dysfunction in narcolepsy type 1
10.19845/j.cnki.zfysjjbzz.2024.0049
- VernacularTitle:1型发作性睡病认知功能障碍的研究进展
- Author:
Yuxin LIU
1
,
2
,
3
,
4
;
Liang XIE
1
,
2
,
3
,
4
;
Liying DENG
1
,
2
,
3
,
4
Author Information
1. 南昌大学江西医学院第二附属医院神经内科，江西 南昌 330006
2. 江西省神经系统肿瘤及脑血管疾病重点实验室，江西 南昌 330006
3. 江西省神经医学重点实验室，江西 南昌 330006
4. 南昌大学神经科学研究所，江西 南昌 330006
- Publication Type:Journal Article
- Keywords:
Narcolepsy type 1;
Cognitive dysfunction;
Orexin;
Functional magnetic resonance imaging
- MeSH:
Orexins
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(3):251-254
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive impairment is a common consequence of narcolepsy type 1 （NT1）， seriously affecting the patients' learning and working. Research evidence has indicated that patients with NT1 exhibit substantial deficits in cognitive domains such as attention， memory， and executive function. The specific mechanisms underlying cognitive impairment in NT1 remain unclear. Animal studies have revealed a close association of insufficient orexin levels in cerebrospinal fluid with cognitive dysfunction. Recent neuroimaging studies with different methodologies have unraveled structural and functional abnormalities in cognitive dysfunction caused by NT1. To date， evidence-based treatment for NT1-associated cognitive impairment is still lacking. This article provides a review of the progress on cognitive impairment in NT1.
- Full text:20250709131916877291型发作性睡病认知功能障碍的研究进展.pdf
