Research advances in circadian rhythm disorders of the glymphatic system in cognitive impairment associated with cerebral small vessel disease
10.19845/j.cnki.zfysjjbzz.2024.0048
- VernacularTitle:胶质淋巴系统昼夜节律紊乱在脑小血管病相关认知功能障碍中的研究进展
- Author:
Chi XIAO
1
;
Yuhua FAN
1
Author Information
1. Department of Neurology， The First Affiliated Hospital of Sun Yat-sen University， Guangzhou 510080， China
- Publication Type:Journal Article
- Keywords:
Cerebral small vessel disease;
Glymphatic system;
Aquapor-4;
BMAL1;
Circadian rhythm;
Cognitive impairment
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(3):246-250
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral small vessel disease （CSVD） is a common cause of vascular dementia and has various etiologies， among which hypertension is the most common risk factor and can induce the disease by damaging the neurovascular glial unit. The process of CSVD leading to cognitive impairment is mainly associated with the disruption of cerebral network connections due to the destruction of cerebral white matter fibers， as well as secondary cortical atrophy and thinning； however， with the discovery of the glymphatic system in recent years， cognitive impairment associated with β-amyloid clearance dysfunction has been considered a new mechanism. The clearance function of the glymphatic system reaches the peak during sleep due to circadian rhythm. Previous studies on the association between CSVD and circadian rhythm have shown that CSVD patients often experience sleep disorders， which is a specific manifestation of circadian rhythm disorders. Such disorders are often neglected， which can lead to a reduction in the function of the glymphatic system in β-amyloid clearance， thereby aggravating cognitive impairment in patients. However， there is still a lack of in-depth studies on the association between the circadian rhythm disorders of the glymphatic system and cognitive impairment in CSVD. This article reviews the studies on sleep rhythm disorders， dysfunction of the glymphatic system， and their influence on cognitive impairment in CSVD.
- Full text:2025070913121815641胶质淋巴系统昼夜节律紊乱在脑小血管病相关认知功能障碍中的研究进展.pdf
