Research advances in telomere-telomerase in neurodegenerative diseases
10.19845/j.cnki.zfysjjbzz.2024.0033
- VernacularTitle:端粒-端粒酶在神经退行性疾病中的研究进展
- Author:
Zhiyue WU
1
;
Erhe XU
1
Author Information
1. Department of Neurology，Xuanwu Hospital，Capital Medical University，Beijing 100053，China
- Publication Type:Journal Article
- Keywords:
Telomere;
Telomerase;
Neurodegenerative diseases;
Alzheimer disease;
Parkinson disease
- MeSH:
Telomere;
Telomerase;
Neurodegenerative Diseases;
Alzheimer Disease;
Parkinson Disease
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(2):169-174
- CountryChina
- Language:Chinese
-
Abstract:
Previous studies mainly used β-amyloid and α-synuclein as the biomarkers for the diagnosis of neurodegenerative diseases. In recent years，studies have shown that telomeres at the end of chromosome can be used as an index to measure the degree of biological aging，and telomere length and telomerase activity may also be used as the blood markers to evaluate the risk，progression，and poor prognosis of neurodegenerative diseases in the elderly；however，there is still a lack of consistency between the research findings in China and globally. Understanding the role of telomere-related biomarkers in age-related diseases can help clinicians learn more about the mechanism of disease development and progression. This article reviews the latest research advances in the telomere-telomerase system in neurodegenerative diseases，in order to introduce the influence of telomere length and telomerase activity on neurodegenerative diseases and their potential mechanisms of action.
- Full text:2025070909325999998端粒-端粒酶在神经退行性疾病中的研究进展.pdf
