Expression of the CYB561D2 gene in glioma tissue and its clinical significance
10.19845/j.cnki.zfysjjbzz.2024.0028
- VernacularTitle:CYB561D2基因在神经胶质瘤组织中的表达及临床意义
- Author:
Chun HUANG
1
;
Heping ZHOU
1
Author Information
1. Department of Neurosurgery，Anqing municipal Hospital，Anqing 246003，China
- Publication Type:Journal Article
- Keywords:
Glioma;
CYB561D2 gene;
Surgical resection;
Quantitative real‐time PCR
- MeSH:
Glioma
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(2):148-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of the CYB561D2 gene in the prognostic evaluation of patients with glioma based on bioinformatics analysis. Methods A total of 78 pathological specimens were collected from the patients with glioma who received surgical treatment in Department of Neurosurgery，Anqing Municipal Hospital，from October 2018 to December 2022 and were enrolled as experimental group，and 32 specimens of normal brain tissue that must be removed during the surgical pathway were enrolled as control group. Quantitative real-time PCR and immunohistochemistry were used to measure the mRNA and protein expression levels of the CYB561D2 gene in both groups. Results The CYB561D2 gene was highly expressed in the glioma tissue of the patients in the experimental group，and the pathological grade of the tumor increased with the increase in the expression of the CYB561D2 gene，while there were no significant mRNA and protein expression levels of the CYB561D2 gene in the control group，with significant differences between the two groups（χ2=2.75 and 2.19，P<0.05）. Conclusion There are significant increases in the mRNA and protein expression levels of the CYB561D2 gene in glioma，suggesting that CYB561D2 is associated with the development，progression，and malignancy of glioma.
- Full text:2025070908522681495CYB561D2基因在神经胶质瘤组织中的表达及临床意义.pdf
