Impact of cerebral microbleeds on the outcome of vascular recanalization in patients with acute cerebral infarction
10.19845/j.cnki.zfysjjbzz.2024.0025
- VernacularTitle:脑微出血对急性脑梗死患者血管再通治疗后的影响
- Author:
Shengqi FU
1
;
Haiqiang QIN
2
Author Information
1. 河南中医药大学第五临床医学院（郑州人民医院）神经内科，河南 郑州 450003hengzhou 450003，China
2. 首都医科大学附属北京天坛医院国家临床神经病学中心，北京 100070
- Publication Type:Journal Article
- Keywords:
Cerebral microbleeds;
Acute cerebral infarction;
Recanalization;
modified Rankin Scale score
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(2):129-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of cerebral microbleeds（CMB）on the prognosis of patients with acute cerebral infarction（ACI）treated with intravenous thrombolysis（IVT）or mechanical thrombectomy（MT）. Methods A total of 738 patients with ACI treated with IVT or MT who were hospitalized in People's Hospital of Zhengzhou from January 2015 to June 2022 were consecutively included. They were evaluated for CMB at admission and the modified Rankin Scale（mRS）score at 3 months. The effects of the presence，location，and load of CMB on the mRS score at 3 months were analyzed. Subgroup analyses were performed for patients with successful recanalization. Results For all patients，the presence or absence of CMB was not significantly associated with the 3-month prognosis（38.0% vs 44.2%，P=0.295），while for the patients with successful recanalization，those without CMB had a significantly higher percentage of a favorable prognosis than those with CMB（56.9% vs 35.8%，P=0.011）. The multivariable logistic regression analysis showed that for all patients，only high-load CMB was significantly associated with the prognosis at 3 months（odds ratio OR=0.017，95% confidence interval CI 0.112-0.808，P=0.017）；in the patients with successful recanalization，the presence of CMB（OR=0.422，95% CI 0.214-0.832，P=0.013），lobar CMB（OR=0.379，95% CI 0.157-0.920，P=0.032），and high-load CMB（OR=0.207，95% CI 0.056-0.760，P=0.018）were significantly associated with the 3-month prognosis. Conclusion The adverse effects of CMB for patients with successful recanalization are more marked as compared with patients with failed recanalization. The presence of CMB，lobar CMB，and high-load CMB are independent predictors of a poor outcome at 3 months in patients with successful recanalization.
- Full text:2025070816305447351脑微出血对急性脑梗死患者血管再通治疗后的影响.pdf
