Research advances in the mechanism of blood-brain barrier disruption by lipopolysaccharide and the onset of sepsis-associated encephalopathy
10.19845/j.cnki.zfysjjbzz.2024.0015
- VernacularTitle:脂多糖破坏血脑屏障与脓毒症相关脑病发生的研究进展
- Author:
Pingchuan LIU
1
;
Jian WANG
1
Author Information
1. Department of Neurology， The Affiliated Hospital of Southwest Medical University， Luzhou 646000， China
- Publication Type:Journal Article
- Keywords:
Blood‑brain barrier;
Lipopolysaccharide;
Central nervous system;
Sepsis‑associated encephalopathy
- MeSH:
Lipopolysaccharides
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(1):77-83
- CountryChina
- Language:Chinese
-
Abstract:
As a barrier structure at the junction of the central nervous system （CNS） and the peripheral environment， the blood-brain barrier （BBB） successfully separates the circulating blood in brain tissue from the CNS and strictly controls material exchange between circulating blood and brain tissue， such as the transport of nutrients and the expulsion of metabolic wastes， thereby maintaining the homeostasis of the CNS. Lipopolysaccharide （LPS） is a component of the cell wall of Gram-negative bacteria and can impair the barrier function of the BBB and further promote the development and progression of sepsis-associated encephalopathy （SAE）. This article reviews the mechanisms by which LPS injures the BBB via central links and other indirect links， as well as the association between these processes and SAE. We believe that when LPS causes damage to the BBB， a large number of immune cells and inflammatory factors enter brain tissue and activate immune cells of the brain， and even the neurovascular units that make up the BBB are affected and mediate the responses such as partial neuroinflammatory response and oxidative stress response， which causes further damage to the BBB. Such a vicious cycle eventually leads to the development of SAE， and therefore， we finally propose that targeted blockade of the disruption of BBB barrier function by LPS can be used for the prevention and treatment of SAE.
- Full text:2025070814170334321脂多糖破坏血脑屏障与脓毒症相关脑病发生的研究进展.pdf
