Relationship between neurofilament light chain protein levels and clinical characteristics in patients with Alzheimer disease
10.19845/j.cnki.zfysjjbzz.2024.0012
- VernacularTitle:阿尔茨海默病患者神经丝轻链蛋白水平与临床特点相关性分析
- Author:
Lulu WANG
1
;
Caijing CHEN
1
Author Information
1. Ningbo No.2 Hospital， Ningbo 315010，China
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Neurofilament light chain protein;
Clinical factor;
Correlation
- MeSH:
Alzheimer Disease
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(1):63-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between neurofilament light chain protein （NfL） and clinical features in patients with Alzheimer disease. Methods We included 58 patients with Alzheimer's disease admitted to Ningbo No. 2 Hospital from June 2020 to December 2021. NfL levels were measured for the 58 patients with Alzheimer's disease. Correlation analysis was performed to study the correlation between NfL and age， disease course， hippocampal grade， Activities of Daily Living（ADL） score， Mini-Mental State Examination （MMSE） score， and Hasegawa Dementia Scale （HDS） score. The Pearson correlation coefficient （r） represented the strength of correlation. Results Among the 58 patients， 33 were females， with a mean NfL level of（24.93±17.07）pg/mL， and 24 were males， with a mean NfL level of 28.14 ± 17.98 pg/mL， which were not significantly different. NfL levels for different educational attainments had no significant difference： illiteracy （7/58），（27.87 ± 14.75）pg/mL；primary school（7/58），（15.22±9.62）pg/mL；middle school （14/58）， （27.95±15.60）pg/mL； high school（4/58），（12.84±2.97）pg/mL； technical secondary school（7/58）， （37.35±26.63）pg/mL； junior college （5/58），（33.79±21.81）pg/mL； and university （7/58），（15.22±9.62）pg/mL. NfL was positively correlated with age （r=0.448） and hippocampal grade（r=0.345）， and not significantly correlated with the course of disease（r=0.045，P>0.05）， ADL score （r=0.242，P>0.05），MMSE score （r=‒0.099，P>0.05），and HDS score （r=‒0.096，P>0.05）. Conclusion Serum NfL levels in patients with Alzheimer disease are positively correlated with age and hippocampal grade on magnetic resonance imaging， but not associated with sex， education attainments， the course of disease，ADL score，MMSE score，and HDS score.
- Full text:2025070813543650723阿尔茨海默病患者神经丝轻链蛋白水平与临床特点相关性分析.pdf
