Construction of a nomogram model for predicting moderate-to-severe white matter hyperintensity in middle-aged and elderly patients with hypertension
10.19845/j.cnki.zfysjjbzz.2024.0011
- VernacularTitle:中老年高血压病患者中重度脑白质高信号列线图模型的构建
- Author:
Ruichen XU
1
;
Feng ZHAO
1
Author Information
1. Department of Radiology， The 8th Division General Hospital of Xinjiang Production and Construction Corps， Shihezi 832000， China
- Publication Type:Journal Article
- Keywords:
White matter hyperintensity;
Magnetic resonance imaging;
Nomogram;
Influencing factor
- MeSH:
Nomograms
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(1):58-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influencing factors for white matter hyperintensity （WMH） in middle-aged and elderly patients with hypertension， and to establish and verity a nomogram prediction model. Methods A total of 198 middle-aged and elderly patients with hypertension and WMH who were hospitalized in our hospital from January 2022 to April 2023 were enrolled. Related clinical data were analyzed， and related data were recorded. A binary logistic regression analysis was used to investigate the independent risk factors for WMH and establish a nomogram， and the receiver operating characteristic （ROC） curve and the calibration curve were used to evaluate the diagnostic efficacy of the nomogram. Results Age， course of hypertension， cystatin C， homocysteine，red blood cell distribution width， and cognitive impairment were the independent influencing factors for WMH in the middle-aged and elderly patients with hypertension. The nomogram established showed good diagnostic efficacy （AUC=0.815， 95% CI 0.756~0.874，P<0.001） and calibration ability （C index=0.794）. Conclusion The nomogram established in this study has a good predictive ability for moderate-to-severe WMH in middle-aged and elderly patients with hypertension and can provide certain help for clinical workers.
- Full text:2025070813474563291中老年高血压病患者中重度脑白质高信号列线图模型的构建.pdf
