Clinical Application and Mechanism of Buyang Huanwutang in Treatment of Chronic Heart Failure： A Review
10.13422/j.cnki.syfjx.20250506
- VernacularTitle:补阳还五汤治疗慢性心力衰竭的临床及机制研究进展
- Author:
Zejun DU
1
;
Linping ZHU
2
;
Xueying WU
1
;
Xiaotong LYU
1
;
Mei ZHAO
2
;
Yuhong LI
3
Author Information
1. Graduate School of Tianjin University of Traditional Chinese Medicine（TCM），Tianjin 301617，China
2. The Second Affiliated Hospital of Tianjin University of TCM，Tianjin 300250，China
3. Institute of TCM，Tianjin University of TCM，Tianjin 301617，China
- Publication Type:Journal Article
- Keywords:
Buyang Huanwutang;
chronic heart failure;
clinical study;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(15):286-294
- CountryChina
- Language:Chinese
-
Abstract:
Chronic heart failure （CHF） is a complex clinical syndrome that the cardiac output is not enough to meet the metabolic needs of the body， or depends on the increase of filling pressure to compensate. Its high morbidity and mortality pose a serious threat to human health， necessitating attention and active intervention. At present， western medicine treatment of CHF is mainly based on diuretics， intravenous vasodilators， intravenous positive inotropic drugs， etc.， which， however， have problems such as long medication cycles， serious side effects， and limited applicable population. Recent studies have shown that traditional Chinese medicine can act in a multi-pathway， multi-component， and multi-target manner， showing unique advantages in the prevention and treatment of CHF. Buyang Huanwutang has the effects of tonifying Qi， activating blood， and dredging collaterals. Clinical and mechanism studies have confirmed that this prescription is effective in treating CHF and its syndromes. The clinical studies can be classified into two categories. Studies of the first category use simple modern medical diagnostic criteria as the inclusion criteria for CHF patients， which can improve the scientificity and objectivity. Studies of the second category uses modern medicine combined with traditional Chinese medicine disease diagnostic criteria for the screening of CHF patients， which helps to improve the accuracy of efficacy evaluation. However， there are problems such as the lack of unified research standards and the insufficiency of mechanism research. In addition， the available studies remain to be classified or summarized. This study systematically sorted out the clinical and mechanism studies of Buyang Huanwutang in the treatment of CHF in recent years to review the research status. In clinical treatment， Buyang Huanwutang can be used alone， or modified， or combined with other prescriptions or Western medicine. The mechanism studies predict that Buyang Huanwutang can ameliorate CHF by regulating the calcium balance， protecting the mitochondrial structure and function， and regulating intestinal flora. This review aims to provide a theoretical basis and practical guidance for the clinical application and optimization and subsequent in-depth study of Buyang Huanwutang in the treatment of CHF.
