Research Progress on Antitumor Effect of AMPK/mTOR Signaling Pathway Regulated by Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20242430
- VernacularTitle:中医药调控AMPK/mTOR信号通路抗肿瘤的研究进展
- Author:
Xiafei ZHENG
1
;
Dongdong LI
2
;
Peimin LIU
2
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450053， China
2. The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002， China
- Publication Type:Review
- Keywords:
adenosine monophosphate activated protein kinase（AMPK）;
mammalian target of rapamycin（mTOR）;
traditional Chinese medicine;
anti-tumor;
mechanistic studies
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(15):268-276
- CountryChina
- Language:Chinese
-
Abstract:
With the increasing incidence and mortality of malignant tumors year by year， the prevention and treatment of malignant tumors has become a hot field of research. Although the existing anti-tumor treatment methods such as surgery， radiotherapy， chemotherapy， immunity and targeting have achieved some results， there are also obvious shortcomings， which are not conducive to the improvement of patients' quality of life and long-term treatment. Therefore， seeking a new efficient and safe treatment has become a hot topic of concern for many oncologists. adenosine monophosphate activated protein kinase（AMPK）/mammalian target of rapamycin（mTOR） signaling pathway can participate in intracellular energy metabolism and affect the pathogenesis and outcome of tumors through multiple mechanisms. It is widely mentioned in the occurrence and development of many tumors. The activity level of this pathway is closely related to the abnormal proliferation and invasion of tumor cells， and is considered as an important pathway for anti-tumor therapy research. The anti-tumor treatment of traditional Chinese medicine（TCM） has significant advantages such as syndrome differentiation and treatment and sample consideration. The study found that flavonoids， alkaloids， polyphenols， saponins and other active components of traditional Chinese medicine， as well as the traditional Chinese medicine compound Xiangbei San， Yiqi Fuzheng Jiedu decoction， Yiqi Fuzheng prescription， etc can activate the AMPK/ mTOR signaling pathway by regulating the expression of AMPK/mTOR signaling pathway and upstream and downstream proteins， thereby inducing tumor cell autophagy and apoptosis， inhibiting tumor angiogenesis and epithelial mesenchymal transformation， regulating aerobic glycolysis and energy metabolism， and reversing drug resistance to exert anti-tumor effects. In this paper， by summarizing the research achievements of TCM anti-tumor in recent years， the specific mechanism of action of TCM regulating AMPK/ mTOR signaling pathway against tumor was discussed， aiming to provide ideas and references for the research and development of anti-tumor new drugs.
