Treatment of Renal Injury in Wilson Disease Based on Pathogenesis of Latent Toxin in Kidney Collaterals
10.13422/j.cnki.syfjx.20242395
- VernacularTitle:基于“肾络伏毒”论治肝豆状核变性肾脏损伤
- Author:
Ke DIAO
1
;
Wenming YANG
2
;
Xiang LI
2
;
Yue YANG
2
;
Yulong YANG
2
;
Zhihong RAO
2
;
Shuzhen FANG
2
;
Yufeng DING
2
Author Information
1. National Resource Center for Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
2. The First Affiliated Hospital of Anhui University of Chinese Medicine，Hefei 230031，China
- Publication Type:Journal Article
- Keywords:
renal injury in Wilson disease;
kidney collaterals;
latent toxin;
etiology;
pathogenesis;
treatment
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(15):132-139
- CountryChina
- Language:Chinese
-
Abstract:
Hepatolenticular degeneration， also known as Wilson disease （WD）， is a hereditary disease caused by mutations in the ATP7B gene， leading to copper metabolism disorders. Gene mutations result in impaired synthesis of copper-binding protein， and abnormal excretion of copper through bile leads to pathological deposition of copper in various organs， ultimately causing multi-organ damage. The insidious onset and low specificity of symptoms make it difficult to diagnose this disease. On the basis of existing studies and the theory of latent toxin， this paper proposes that latent toxin in kidney collaterals is the main pathogenesis of renal injury in WD. It is pointed out that health Qi deficiency and latent pathogen are the premises for the occurrence of this disease， and the transformation of latent pathogen into toxin is the ley pathological process. Toxin damaging kidney collaterals is the ultimate result. According to the pathogenesis， this paper proposes the treatment principle of reinforcing healthy Qi and resolving toxin and treatment based on syndrome differentiation. This review provides new ideas for the diagnosis and treatment of renal injury in WD with traditional Chinese medicine.
