Research progress on hemolysis of rotary blood pump
- VernacularTitle:旋转式血泵溶血的研究进展
- Author:
Teng JING
1
;
Jianan CHENG
1
;
Haoran SUN
1
;
Aidi PAN
1
Author Information
1. National Research Center of Pumps, Jiangsu University, Zhenjiang, 212013, Jiangsu, P. R. China
- Publication Type:Journal Article
- Keywords:
Rotary blood pump;
hemolysis;
shear stress;
structural optimization;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2025;32(04):560-566
- CountryChina
- Language:Chinese
-
Abstract:
Hemolysis is one of the main complications associated with the use of ventricular assist devices. The primary factors influencing hemolysis include the shear stress and exposure time experienced by red blood cells. In addition, factors such as local negative pressure and temperature may also impact hemolysis. The different combinations of hemolysis prediction models and their empirical constants lead to significant variations in prediction results; compared to the power-law model, the OPO model better accounts for the complexity of turbulence. In terms of improving hemolytic performance, research has primarily focused on optimizing blood pump structures, such as adjustments to pump gaps, impellers, and guide vanes. A small number of scholars have studied hemolytic performance through control modes of blood pump speed and the selection of blood-compatible materials. This paper reviews the main factors influencing hemolysis, prediction methods, and improvement strategies for rotary blood pumps, which are currently the most widely used. It also discusses the limitations in current hemolysis research and provides an outlook on future research directions.
