Successful Pregnancy after Autologous Cryopreserved Ovarian Tissue Transplantation in a Cervical Cancer Patient： the First Reported Case in China
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0314
- VernacularTitle:国内首例宫颈癌自体卵巢组织冻存移植成功妊娠
- Author:
Yubin LI
1
;
Yang ZHANG
2
;
Tian MENG
1
;
Bing CAI
1
;
Chuling WU
2
;
Changxi WANG
3
;
Hongwei SHEN
2
;
Guofen YANG
2
Author Information
1. Department of Reproduction， The First Affiliated Hospital， Sun Yat-sen University， Guangzhou 510080， China
2. Department of Gynecology， The First Affiliated Hospital， Sun Yat-sen University， Guangzhou 510080， China
3. Department of Organ Transplantation， The First Affiliated Hospital， Sun Yat-sen University， Guangzhou 510080， China
- Publication Type:Journal Article
- Keywords:
multidisciplinary collaboration;
ovarian tissue cryopreservation;
ovarian tissue transplantation;
cervical cancer;
ovarian function;
fertility preservation
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(3):498-505
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the efficacy of ovarian tissue cryopreservation and autologous transplantation in preserving fertility and ovarian endocrine function in patients with cervical cancer. MethodsA 26-year-old patient with stage ⅡA1 cervical cancer underwent ovarian tissue harvesting and cryopreservation during cancer surgery. Following complete remission of the cancer， autologous ovarian tissue transplantation was performed. Follow-up monitoring included assessment of menopausal symptoms， hormone levels， and follicular development. ResultsSix months after transplantation， follicle-stimulating hormone levels decreased to 6.60 U/L， and estradiol levels increased from ＜10.00 ng/L to 89.00 ng/L. At 10 months after transplantation， ultrasound monitoring confirmed follicular development and physiological ovulation in the transplanted ovarian tissue. By 15 months after transplantation， follicle-stimulating hormone levels remained stable at 7.24 U/L， and estradiol levels further increased to 368.00 ng/L. Over 2 years after transplantation， the patient successfully gave birth to a healthy baby through assisted reproductive technology. ConclusionThe restoration of endocrine and ovulation functions in the transplanted cryopreserved ovarian tissue， followed by successful pregnancy， demonstrates the clinical success of ovarian tissue transplantation.
