Glutamate Receptor Antagonists Attenuate Stereotyped Behaviors via Modulating BDNF Levels in Obsessive-complusive Disorder Model Mice
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0312
- VernacularTitle:谷氨酸受体拮抗剂可通过调节脑源性神经营养因子水平改善强迫症模型小鼠的刻板行为
- Author:
Weijie WANG
1
;
Yuchong LUO
1
;
Dongmiao HUANG
1
;
Chen YANG
1
;
Jihui YUE
1
;
Xianglan WANG
1
;
Shenglin WEN
1
Author Information
1. Department of Psychiatry， The Fifth Affiliated Hospital of Sun Yat-sen University， Zhuhai 519000， China
- Publication Type:Journal Article
- Keywords:
obsessive-compulsive disorder;
RU24969;
glutamate receptor antagonist;
brain-derived neurotrophic factor;
blood-brain barrier
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(3):475-485
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore whether fluoroethylnormemantine （FENM）， an NMDA receptor antagonist， could improve compulsive-like behaviors and to investigate its underlying mechanisms in the RU24969-induced obsessive-compulsive disorder （OCD） mouse model. MethodsThirty-two mice were randomly assigned to four groups： Saline （n=8）， RU24969 （n=8）， RU+FENM （n=8）， and FENM （n=8）. Mice received FENM or an equivalent volume of saline for pre-treatment， followed by RU24969 or saline for model induction 30 minutes later. Behavioral tests were performed 1 hour after modeling， and serum samples were collected to measure the level of brain-derived neurotrophic factor （BDNF）. Evans Blue dye was intravenously injected to assess dye content in brain tissue， thereby evaluating potential blood-brain barrier damage. ResultsFENM treatment significantly improved repetitive stereotyped circling behavior （F=39.850， P＜0.001） and alleviated persistent motor activity （F=50.200， P＜0.001） in RU24969 model mice. Additionally， FENM treatment significantly increased serum BDNF level in RU24969-induced OCD mice （F=18.930， P＜0.001）. ConclusionsFENM ， an NMDA receptor antagonist， may alleviate compulsive behaviors in OCD mice by modulating BDNF levels ， thereby exerting anti-compulsive effects. Neither the RU24969 model nor FENM treatment significantly affectes blood-brain barrier integrity.
