Research Progress on the Signaling Pathway of the Blood-Brain Barrier Injuries Induced by PFOS
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0303
- VernacularTitle:全氟辛烷磺酸诱导血脑屏障损伤的信号通路研究进展
- Author:
Zhiyong XIAO
1
;
Churong WEI
1
Author Information
1. School of Basic Medicine， Jinggangshan University， Ji'an 343009， China
- Publication Type:Review
- Keywords:
perfluorooctane sulfonate;
blood-brain barrier;
neurotoxicity;
mechanism;
signaling pathway
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(3):384-390
- CountryChina
- Language:Chinese
-
Abstract:
Perfluorooctane sulfonate （PFOS） has significant biotoxicity and can disrupt the structure and function of the blood-brain barrier. PFOS exposure can lead to the degradation of tight junction proteins in the blood-brain barrier and damage to astrocytes， resulting in increased permeability of the blood-brain barrier， as well as the activation of multiple signaling pathways， including PI3K/AKT， p38 MAPK， oxidative stress， and calcium signaling pathways. Damage to the blood-brain barrier may trigger various neurological diseases， and PFOS affects the function of the blood-brain barrier through multiple mechanisms， thereby interfering with the normal operation of the central nervous system. This article aims to review the research progress on the signaling pathways related to PFOS-induced blood-brain barrier damage and suggests that future studies could focus on developing more precise in vivo models， utilizing advanced molecular biology techniques to reveal more detailed molecular mechanisms， and exploring the synergistic effects of PFOS with other environmental toxins， in order to provide scientific evidence for the clinical prevention and treatment of PFOS-induced neurological diseases.
