Research Progress in Bacteria and Their Metabolites Influence on the Development and Treatment of Breast Cancer
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0301
- VernacularTitle:细菌及其代谢物影响乳腺癌发展及治疗的研究进展
- Author:
Dandan SUN
1
;
Guobao TIAN
2
Author Information
1. School of Medicine， Xizang Minzu University， Xianyang 712000， China
2. School of Medicine， Sun Yat-sen University， Shenzhen 518107， China
- Publication Type:Review
- Keywords:
breast cancer;
bacteria;
metabolites;
tumor;
treatment
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(3):361-370
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is one of the most common cancers in women， which seriously threatens women's health. Early diagnosis and precise treatment of breast cancer are helpful to improve the prognosis of patients. This article summarizes the research status of bacteria and their metabolites in the development and treatment of breast cancer， and discusses in detail the role and mechanism of bacteria and their metabolites in the development and intervention of breast cancer. These mechanisms include regulation of inflammation and immune response， DNA damage， and regulation of cell biological characteristics. Engineering bacteria have become one of the hotspots in the field of breast cancer treatment in recent years due to their natural advantages in targeting tumors and activating immunity. This article further summarizes the research progress of engineered bacteria in the treatment of breast cancer， aiming to provide an important reference for formulating targeted treatment strategies and improving the prognosis of patients. Although bacteria and their metabolites affect the development and treatment of breast cancer through a variety of mechanisms， and can enhance the therapeutic effect of cancer and reduce the adverse effects of treatment， the clinical application of bacteria in anti-breast cancer therapy still faces numerous challenges. The highly individualized composition of bacteria leads to the lack of universality of treatment， and the complex interaction between bacteria and host further increases the difficulty of research. In the future， it is urgent to further explore the mechanism of bacteria and their metabolites affecting the development and treatment of breast cancer， and promote the clinical application of bacteria in anti-breast cancer treatment.
