Research progress on the role of JAK2/STAT3 signaling pathway in cerebral ischemia-reperfusion injury and TCM intervention
- VernacularTitle:JAK2/STAT3信号通路在脑缺血再灌注损伤中的作用及中药干预研究进展
- Author:
Zhijuan TAO
1
;
Qinyi ZHOU
1
;
Zhang ZHANG
1
Author Information
1. College of Chinese Medicine，Jiangxi University of Chinese Medicine，Nanchang 330004，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
cerebral ischemia-reperfusion injury;
JAK2/STAT3 signaling pathway;
mechanism
- From:
China Pharmacy
2025;36(12):1547-1552
- CountryChina
- Language:Chinese
-
Abstract:
Janus kinase 2（JAK2）/signal transducer and activator of transcription 3（STAT3） signaling pathway regulates multiple processes in neurons， including growth， development， proliferation and differentiation， and is closely associated with the onset， progression and treatment of cerebral ischemia-reperfusion injury （CIRI）. This article provides an overview of the JAK2/ STAT3 signaling pathway and its relationship with CIRI， followed by a comprehensive review of the current research status on the regulation of the JAK2/STAT3 signaling pathway by traditional Chinese medicine （TCM） to ameliorate CIRI. Among them， TCM monomers and compound prescriptions such as glycyrrhetinic acid， triptolide， and Taohong siwu decoction can inhibit inflammatory responses， enhance cellular autophagy， and suppress apoptosis by inhibiting the JAK2/STAT3 signaling pathway， thereby alleviating CIRI. In addition， TCM monomers and compound prescriptions like astragaloside Ⅳ， ginkgolide K， and Qingnao dripping pills can mitigate CIRI by activating the JAK2/STAT3 signaling pathway to inhibit oxidative stress， promote angiogenesis， and enhance neuronal survival rates.
