Research progress on the mechanism of action of traditional Chinese medicine regulating Nrf2 signaling pathway to improve sepsis-induced lung injury
- VernacularTitle:中药调控Nrf2信号通路改善脓毒症肺损伤的作用机制研究进展
- Author:
Yang LI
1
;
Ruifen ZHANG
2
;
Tingting JIA
2
;
Hairong ZHANG
2
;
Jian ZHAO
2
;
Xinsheng HUANG
2
;
Xiao LI
2
;
Xin ZHONG
2
Author Information
1. College of Traditional Chinese Medicine，Inner Mongolia Medical University，Hohhot 010050，China
2. ICU，Inner Mongolia Hospital of Traditional Chinese Medicine，Hohhot 010050，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
effective ingredients;
compound preparations;
sepsis;
lung injury;
Nrf2 signaling
- From:
China Pharmacy
2025;36(12):1530-1535
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis-induced lung injury is a common type of sepsis complicated with multiple organ dysfunction syndrome， whose uncontrolled inflammatory response and oxidative stress are the key pathological mechanisms. As an important pathway of anti-inflammatory and anti-oxidative stress， the nuclear factor-erythroid 2-related factor 2 （Nrf2） signaling pathway is very important in the occurrence and development of sepsis-induced lung injury. This review summarizes relevant research conducted over the past decade on the regulation of the Nrf2 signaling pathway by traditional Chinese medicine （TCM） to ameliorate sepsis- induced lung injury. It has been found that 14 kinds of TCM effective ingredients （including five types of compounds： flavonoids， terpenes， alkaloids， saponins， phenols） and 6 kinds of compound preparations （including three types of formulas： heat-clearing and detoxifying formulas， purgative formulas for promoting bowel movement， and formulas for reinforcing vital qi and consolidating the constitution） can inhibit inflammatory responses and oxidative stress by activating Nrf2 signaling pathway and intervening in related pathways such as those involving Kelch-like ECH-associated protein 1， heme oxygenase-1， antioxidant response element and AMP-activated protein kinase， thereby alleviating sepsis-induced lung injury.
