Risk factors of ineffective eradication therapy of adult Helicobacter pylori infection：a meta-analysis
- VernacularTitle:成人幽门螺杆菌感染根除治疗失败危险因素的Meta分析
- Author:
Zhifeng TANG
1
;
Guoming GAO
2
;
Shuoquan LI
3
;
Agang QU
1
;
Lixia GOU
4
Author Information
1. Ward 1 of Gastroenterology Department，Tianshui Integrated Chinese and Western Medicine Hospital，Gansu Tianshui 741020，China
2. Dept. of Interventional Radiology，Tianshui Integrated Chinese and Western Medicine Hospital，Gansu Tianshui 741020，China
3. Dept. of Pharmacy，Tianshui Integrated Chinese and Western Medicine Hospital，Gansu Tianshui 741020，China
4. Dept. of Hyperbaric Oxygen Therapy Center，Tianshui Integrated Chinese and Western Medicine Hospital，Gansu Tianshui 741020，China
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
adults;
eradication therapy;
failure;
influencing factors;
meta-analysis
- From:
China Pharmacy
2025;36(12):1525-1529
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To systematically evaluate the risk factors for ineffective eradication therapy of adult Helicobacter pylori （Hp） infection. METHODS Retrieved from PubMed，Web of Science， the Cochrane Library， Embase， CNKI， VIP and Wanfang Data， cohort studies and case-control studies on the eradication therapy for Hp infection in adult patients were searched from Jan. 2000 to Jul. 2024. After screening literature， extracting data， and evaluating the quality of literature， RevMan 5.3 software was used for meta-analysis， and sensitivity analysis and publication bias analysis were also performed. RESULTS A total of 19 articles were included， all of which were cohort studies， involving 9 931 patients in total. Among them， 1 929 patients were ineffective in eradication therapy， with the ineffective rates ranging from 8.02% to 33.33%. Meta-analysis showed that age＜50 years [OR＝1.33， 95%CI （1.12，1.57）， P＜0.001]， body mass index （BMI）＞25 kg/m2 [OR＝1.87， 95%CI （1.35， 2.59）， P＝ 0.000 2]， a history of smoking [OR＝1.62， 95%CI（1.35， 1.95）， P＜0.001]， a history of drinking [OR＝1.93， 95%CI（1.47， 2.54）， P＜0.001]， living in a rural area [OR＝1.74， 95%CI（1.41， 2.15）， P＜0.001]， having non-peptic ulcer [OR＝3.45， 95%CI （1.75， 6.67）， P＝0.000 3]， a family members’ infection history [OR＝4.72， 95%CI（3.32， 6.74）， P＜0.001]， poor treatment compliance [OR＝4.89， 95%CI （3.07， 7.79）， P＜0.001]， amoxicillin resistance [OR＝3.42， 95%CI （1.95， 6.00）， P＜0.001] and clarithromycin resistance [OR＝8.14， 95%CI（5.00， 13.24）， P＜0.001] had significant impacts on ineffective eradication therapy of Hp infection in adults. Sensitivity analysis and publication bias analysis showed that the result of this study was robust and reliable. CONCLUSIONS Age＜50 years， BMI＞25 kg/m， a history of smoking， a history of drinking， living in a rural area， having non-peptic ulcer， a family members’ infection history， poor treatment compliance， amoxicillin resistance and clarithromycin resistance are risk factors for failure of Hp infection eradication therapy in adults.
