Effects of Acupuncture at Channel Points on Serum 5-Hydroxytryptamine， Vasoactive Intestinal Peptide， and Glucagon-Like Peptide-1 in Patients with Functional Dyspepsia of Spleen-Stomach Weakness Syndrome
10.13288/j.11-2166/r.2025.13.010
- VernacularTitle:针刺经穴对脾胃虚弱型功能性消化不良患者血清5-羟色胺、血管活性肽及胰高血糖素样肽-1的影响
- Author:
Duoduo LI
1
;
Zenghui YUE
2
;
Wei'ai LIU
1
Author Information
1. The Second Affiliated Hospital of Hunan University of Chinese Medicine，Changsha，410005
2. Hunan University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
functional dyspepsia;
spleen-stomach weakness syndrome;
channel points;
acupuncture;
5-hydroxytryptamine;
vasoactive intestinal peptide;
glucagon-like peptide-1
- From:
Journal of Traditional Chinese Medicine
2025;66(13):1357-1362
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effects of acupuncture at channel points in treating functional dyspepsia （FD） patients of spleen-stomach weakness syndrome and to explore its potential mechanism. MethodsSixty FD patients of spleen-stomach weakness syndrome were randomly divided into an acupuncture group and a domperidone group， with 30 patients in each group. Acupuncture group was given acupuncture at Zusanli （ST36）， Neiguan （PC6）， Gongsun （SP4）， and Yinlingquan （SP9） using even reinforcing-reducing method. Unilateral points were selected alternately on the left and right sides， once daily， for 30 minutes each session， 5 sessions per course， and a 2-day interval between courses. Domperidone group was given domperidone tablets orally， one tablet each time， three times daily， 15~30 minutes before meals. The total course of treatment was 4 weeks in both groups. Pairwise comparisons of the symptom scores including postprandial fullness and discomfort， early satiety， epigastric pain， and epigastric burning discomfort， and the levels of serum 5-hydroxytryptamine （5-HT）， vasoactive intestinal peptide （VIP）， and glucagon-like peptide-1 （GLP-1） were conducted at pre-treatment， 4， and 8 weeks post-treatment. The clinical efficacy was analyzed and evaluated after treatment. ResultsCompared with baseline， the symptom scores of postprandial fullness and discomfort， early satiety， epigastric pain and epigastric burning discomfort and the levels of serum 5-HT， VIP and GLP-1 of both groups were significantly decreased after 4 weeks and 8 weeks treatment （P＜0.05）. At 4 weeks post-treatment， all symptom scores and the levels of 5-HT and GLP-1 of the acupuncture group were significantly lower than those of the domperidone group （P＜0.05）. At 8 weeks post-treatment， the symptom scores of postprandial fullness and discomfort， early satiety and epigastric pain and the levels of 5-HT and VIP of the acupuncture group were significantly lower than those of the domperidone group （P＜0.05）. The total effective rate of the acupuncture group （96.67%， 29/30） was higher than that of the domperidone group （86.67%， 26/30， P＞0.05）. ConclusionAcupuncture at channel points shows good clinical efficacy in the treatment of spleen-stomach weakness syndrome FD， and its mechanism may be related to the decreased levels of 5-HT， VIP， and GLP-1 in serum.
