Application and Production of Systematic Review and Meta-Analyses of Preclinical Studies in the Field of Traditional Chinese Medicine
10.13288/j.11-2166/r.2025.13.006
- VernacularTitle:中医药领域临床前研究系统评价和Meta分析的应用与制作要点
- Author:
Wenya WANG
1
;
Chengyang JING
1
;
Lanjun SHI
1
;
Bin MA
2
;
Xing LIAO
1
Author Information
1. Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences，Beijing，100700
2. Evidence-Based Medicine Center，School of Basic Medical Sciences，Lanzhou University
- Publication Type:Journal Article
- Keywords:
preclinical studies;
systematic review;
meta-analysis;
evidence system of traditional Chinese medicine
- From:
Journal of Traditional Chinese Medicine
2025;66(13):1333-1339
- CountryChina
- Language:Chinese
-
Abstract:
Preclinical studies include pharmacology， toxicology， pharmacokinetics research of animal experiments and in vitro experiments， which are crucial steps in the pre-marketing drugs and medical products， and are essential for exploring the mechanisms of traditional Chinese Medicine （TCM） therapeutic mechanism and promoting clinical translation. Systematic reviews and meta-analyses of preclinical studies in the field of TCM can comprehensively integrate preclinical evidence， consolidate research findings， assess the quality and risk of bias of included studies， enhance the utilization of research results， reduce resource waste， and promote the iterative optimization of TCM research models and evaluation indicators. This article introduced the process and methodology of conducting systematic review and meta-analyses of preclinical studies in TCM from nine steps， defining the research question， forming a research team， writing and registering a study protocol， conducting a comprehensive search， screening literature， evaluating included studies， extracting data， synthesizing data （meta-analysis）， and reporting systematic reviews. It aims to provide methodological references for conducting systematic reviews and meta-analyses of preclinical studies in TCM and to promote the establishment and improvement of the evidence system in the field of TCM.
