Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?.
10.4078/jrd.2017.24.3.127
- Author:
Federico CACCIAPUOTI
1
Author Information
1. Department of Internal Medicine, Second University of Naples, Naples, Italy. fulviocacciapuoti@gmail.com
- Publication Type:Review
- Keywords:
Uricemia;
Uric acid;
Homocysteine;
MTHFR C677T polymorphism
- MeSH:
Adenosine;
Atherosclerosis;
Homocysteine;
Hyperuricemia*;
Methylenetetrahydrofolate Reductase (NADPH2);
Polymorphism, Genetic;
Purines;
Uric Acid
- From:Journal of Rheumatic Diseases
2017;24(3):127-130
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hyperuricemia is related to metabolic syndrome, and is defined as an over-production or under-excretion of uric acid (UA), with increased UA serum concentration. Among other causes, Hyper-homocysteinemia (H-Hcy) can be responsible for hyperuricemia. The mechanisms underlying the association between these two conditions are unclear, but increased UA serum levels can be a consequence of renovascular atherosclerosis, with reduced UA excretion. An alternative hypothesis is the over-production of UA from adenosine (originating from S-adenosyl-homocysteine). Genetic polymorphism (C677T) of methylenetetrahydrofolate reductase (MTHFR) may contribute. A possible mechanism is purines biosyinthesis originating from this gene variant. However, the results obtained from several studies and meta-analyses of the relationship between H-Hcy and hyperuricemia are ambivalent, and broader research is needed.
