Mendelian Randomization Analysis of Correlation Between Interleukin and Risk of Gynecological Tumors
10.3971/j.issn.1000-8578.2025.24.0994
- VernacularTitle:白介素与妇科肿瘤发病风险相关的孟德尔随机化分析
- Author:
Xinying ZHOU
1
;
Hu ZHANG
2
;
Haiyan DAI
3
Author Information
1. Department of Gynecology, Li Huili Hospital, Ningbo Medical Center, Ningbo 315000, China.
2. Department of Obstetrics and Gynecology, Pudong Hospital Affiliated to Fudan University, Shanghai 200120, China.
3. Department of Obstetrics and Gynecology, Jinqi New Hongqiao Healthy Choice Medical Center, Shanghai 201107, China.
- Publication Type:CLINICALRESEARCH
- Keywords:
Interleukin;
Mendelian randomization;
Cervical cancer;
Endometrial cancer;
Uterine leiomyoma
- From:
Cancer Research on Prevention and Treatment
2025;52(6):511-519
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between different interleukins (ILs) and gynecological tumors, including cervical cancer, endometrial cancer, and uterine leiomyoma using two-sample Mendelian randomization (MR) analysis. Methods IL and gynecological tumor data were obtained from European populations by using the IEU OpenGWAS open database. Two-sample MR analysis was applied, different interleukins were used as exposure factors, significant SNP in GWAS data were selected as instrumental variables, and the instrumental variables were independent of each other. The risk of three kinds of gynecological tumors was analyzed separately to explore the causal relationship between ILs predicted by genes and outcome indicators. The TwoSampleMR package in R language (4.3.1) software was used for statistical analysis. MR analysis was performed using inverse variance weighted, MR Egger regression, weighted median, simple mode, and weighted mode methods. Results IL-18 receptor 1 (P=0.039) and IL-24 (P=0.025) were negatively correlated with the risk of cervical cancer. IL-4 (P=0.040), IL-21 (P=0.026), and IL-37 (P=0.027) were positively correlated with the risk of endometrial cancer. IL-15 receptor subunit alpha (P=0.005) was negatively correlated with the risk of endometrial cancer. IL-17A (P=0.005) and IL-37 (P=0.018) were negatively correlated with the risk of uterine leiomyoma. IL-21 (P=0.035) was positively correlated with the risk of uterine leiomyoma. Conclusion Genetically predicted IL-4, IL-15Rα, IL-17A, IL-18R1, IL-21, IL-24, and IL-37 are causally associated with the risk of three gynecological tumors. Further exploration of the molecular mechanism of ILs in gynecological tumors may provide potential therapeutic targets for the treatment of gynecological tumors.
