Causal Relationship Between Colorectal Cancer and Common Psychiatric Disorders: A Two-sample Mendelian Randomization Study
10.3971/j.issn.1000-8578.2025.24.1154
- VernacularTitle:基于双样本孟德尔随机化探讨结直肠癌与常见精神类疾病的因果关系
- Author:
Yuan YAO
1
;
Mingze YANG
1
;
Chen LI
1
;
Haibo CHENG
2
,
3
Author Information
1. The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
2. The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
3. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing 210023, China.
- Publication Type:CLINICALRESEARCH
- Keywords:
Colorectal cancer;
Depression;
Anxiety;
Bipolar disorder;
Schizophrenia;
Mendelian randomization;
Gut-brain axis
- From:
Cancer Research on Prevention and Treatment
2025;52(6):496-501
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the causal relationships between colorectal cancer (CRC) and prevalent psychiatric disorders through a two-sample Mendelian randomization approach. Methods Utilizing publicly available genome-wide association study data, we explored the connections between CRC and various psychiatric disorders, including depression, anxiety, bipolar disorder, and schizophrenia. We applied three statistical analyses: inverse variance weighting, MR-Egger, and median weighting. Sensitivity analyses were conducted to ensure the reliability and validity of the results. Results Inverse variance weighting analysis showed no significant links between CRC and depression (P=0.090), anxiety (P=0.099), or schizophrenia (P=0.899). Conversely, a significant inverse relationship was found with bipolar disorder (P=0.010). Conclusion No causal connection exists between CRC and the psychiatric conditions of depression, anxiety, or schizophrenia. However, CRC may have a causal association with a reduced risk of bipolar disorder, further supporting the existence of the gut-brain axis.
