Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer Cells
10.3971/j.issn.1000-8578.2025.24.0951
- VernacularTitle:BAIAP2L1在宫颈癌中表达的临床意义及其对宫颈癌细胞恶性表型的影响
- Author:
Jueying ZHAO
1
;
Zhuoying HAN
1
;
Lulu FENG
1
;
Chenlong WANG
1
;
Li ZHANG
1
;
Chao LUO
1
;
Qilong WANG
1
Author Information
1. Department of Central Laboratory, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, China.
- Publication Type:BASICRESEARCH
- Keywords:
BAIAP2L1;
Cervical cancer;
Metastasis;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2025;52(6):481-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression characteristics of BAIAP2L1 in cervical cancer (CC) and its regulatory role in tumor cell metastasis. Methods The correlation between BAIAP2L1 expression and clinical prognosis was analyzed by using a public database. GO pathway enrichment and clinicopathological correlation analyses were conducted by employing R language. The effect of BAIAP2L1 knockdown on CC cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) were further investigated through gene silencing approaches. Results BAIAP2L1 expression was significantly upregulated in CC tissues (Padj <0.001) and it was identified as an independent risk factor for patient mortality (HR=2.808, P=0.03). Elevated BAIAP2L1 levels showed significant correlations with poor overall survival, advanced T/N stage, recurrence, and metastasis (all P<0.05). Functional enrichment analysis revealed its involvement in tumor metastasis-related pathways. The knockdown of BAIAP2L1 significantly attenuated CC cell proliferation, invasion, and migration and suppressed key EMT processes (all P<0.05). Conclusion BAIAP2L1 is overexpressed in CC tissues and associated with patient prognosis and metastasis. The targeted inhibition of BAIAP2L1 can effectively curb tumor progression.
