Research Progress on Regulation of Tumor Immune Microenvironment via Reactivation of Unbalanced Mitochondria in Traditional Chinese Medicine
10.3971/j.issn.1000-8578.2025.25.0025
- VernacularTitle:中医药重激活失衡线粒体调节肿瘤免疫微环境的研究进展
- Author:
Mengying PENG
1
;
Lihong FAN
2
;
Changxing SHEN
1
Author Information
1. Department of Oncology, Shanghai Baoshan Luodian Hospital, Shanghai 201203, China.
2. Department of Respiration, The Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200000, China.
- Publication Type:SPECIALFEATURE
- Keywords:
Mitochondria;
Chinese medicine;
Malignancy;
Mitochondrial imbalance;
Tumor immune microenvironment
- From:
Cancer Research on Prevention and Treatment
2025;52(6):448-453
- CountryChina
- Language:Chinese
-
Abstract:
The health of the human body is the result of the dynamic interplay between immunity and various microorganisms. Furthermore, the health of the mitochondrial grid determines the strength of immunity. Mitochondrial imbalance leads to the metabolic remodeling of intracellular nutrients, which accelerates the occurrence and development of tumors. The theory of yin and yang and the theory of visceral outward manifestation are the foundation and core of traditional Chinese medicine (TCM) theory, which guides the clinical diagnosis and treatment of TCM. Yang Qi is the driving force behind the metabolism and physiological functions of the human body; it is also the adenine nucleoside triphosphate produced efficiently by mitochondrial aerobic respiration. The main transport of spleen refers to the biological oxidation process of food in the mitochondria, and its normal function is closely related to the integrity of the mitochondrial structure and function of the cell. Therefore, warming yang and strengthening the spleen essentially means restoring the high production capacity of the mitochondria. Rebuilding damaged mitochondrial function, improving efficiency, and boosting the energy level of the neuro-endocrine-immune network are the key factors contributing to the body’s ability to resist disease and return to health.
