The inhibitory effect of lidocaine by different administration routes on cardiovascular stress response during tracheal intubation of anesthetic intubation
10.12206/j.issn.2097-2024.202502009
- VernacularTitle:利多卡因不同给药途径对麻醉诱导气管插管心血管应激反应的抑制作用
- Author:
Jing GUO
1
;
Jinlong KANG
1
;
Qiang LI
1
;
Lin ZHAO
1
;
Ji LIU
1
;
Xuewu XU
1
Author Information
1. Department of anesthesiology, the ninth medical center of PLA hospital, Beijing 100101, China.
- Publication Type:Medicine&Clinical
- Keywords:
lidocaine;
tracheal intubation;
general anesthesia;
cardiovascular response;
stress
- From:
Journal of Pharmaceutical Practice and Service
2025;43(6):303-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effects of lidocaine administered through different routes on cardiovascular stress responses during anesthesia tracheal intubation. Methods Total 120 patients scheduled for elective surgery under general anesthesia were randomly divided into three groups: intravenous injection group （group IV）, throat spray group （group LJ）, and control group （group CT）, with 40 patients in each. Group IV received 50 mg of lidocaine via intravenous injection 1 minute before tracheal intubation. Group LJ received 50 mg of lidocaine sprayed into the pharyngeal cavity, glottis, and subglottic area. Group CT did not receive any treatment, and the remaining procedures were performed following the routine general anesthesia induction protocol. Heart rate （HR）, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, and mean arterial pressure （MAP） were recorded at four time points: T0 （before tracheal intubation）, T1 （immediately after tracheal intubation）, T2 （3 minutes after intubation）, and T3 （5 minutes after intubation）. Statistical analysis of the data was performed using SPSS 22.0. Results There were no significant differences in HR at various time points within the group LJ. The changes in HR in the group IV and group CT were different statistically from those in the throat spray group. The blood pressure of patients in all three groups increased to varying degrees immediately after tracheal intubation, with the group CT showing particularly significant changes that differed significantly from both the group IV and the group LJ. The group LJ rapidly returned to levels close to those before intubation. Conclusion The preventive effects of lidocaine on stress responses during tracheal intubation were different depending on the route of administration. The inhibitory preventive effect of the throat spray method was superior to that of intravenous lidocaine, especially in preventing changes in heart rate.
