Progress on elimination of radioactive nuclides by polysaccharides

VernacularTitle:多糖用于放射性核素清除的研究进展
Author: Shuxiu ZHANG ^{1
,

2} ; Bochuan YUAN ² ; Lina DU ^{1
,

2} ; Yiguang JIN ²
Author Information

1. Department of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2. Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China.
Publication Type:Reviews
Keywords: polysaccharides; radioactive nuclide; chelating agent; adsorption agent
From: Journal of Pharmaceutical Practice and Service 2025;43(6):270-274
CountryChina
Language:Chinese
Abstract: Radionuclides can be hazardous by absorbed through the skin, respiratory and digestive tracts. Chelating agents and adsorbents already could effectively remove them, however traditional chelators have side effects such as nephrotoxicity, teratogenicity, and embryotoxicity. As a new type of nuclide adsorbent, polysaccharide has the advantages of safety, biocompatibility, and high clearance rate. In this paper, the main types and perniciousness of radionuclides, and the latest research of polysaccharides in radionuclide removal were summarized. The application of polysaccharide as an effective adsorption molecule for radio nuclides in nuclear wars, nuclear accidents and other sudden nuclear events is promising.