Research progress of role and mechanism of ferroptosis in acute kidney injury
- VernacularTitle:铁死亡在急性肾损伤中作用及机制的研究进展
- Author:
Jian WANG
1
;
Wei JI
;
Bingyu REN
;
Zhongbo LI
;
Qian HE
Author Information
- Publication Type:Research Article
- Keywords: acute kidney injury; ferroptosis; lipid peroxidation; glutathione peroxidase 4
- From: Journal of Clinical Medicine in Practice 2024;28(18):129-134
- CountryChina
- Language:Chinese
- Abstract: Ferroptosis is a novel strategy for regulating cell death, and its occurrence is closely related to intracellular iron metabolism, lipid metabolism, amino acid metabolism, and various signaling pathways. Ferroptosis plays a pivotal role in the pathogenesis of acute kidney injury (AKI). Ferroptosis may serve as an important target for the treatment of AKI caused by various reasons such as ischemia-reperfusion injury, nephrotoxic drugs, rhabdomyolysis syndrome, sepsis, and so on. This paper reviewed the regulatory mechanisms of ferroptosis and its research progress in AKI.
