Correlations of serum cell division cycle 42, β2-microglobulin and fibulin 1 levels with abdominal aortic calcification in patients with maintenance hemodialysis
- VernacularTitle:维持性血液透析患者血清细胞分裂周期蛋白42、β2微球蛋白、腓骨蛋白1水平与腹主动脉钙化的相关性
- Author:
Junfang YAN
1
;
Qian ZONG
;
Liang YUAN
;
Ting BAO
;
Wenting XU
Author Information
- Publication Type:Research Article
- Keywords: maintenance hemodialysis; cell division cycle 42; β2-microglobulin; fibulin 1; abdominal aortic calcification; correlation
- From: Journal of Clinical Medicine in Practice 2024;28(18):47-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations of serum cell division cycle 42 (CDC-42), β2-microglobulin (β2-MG) and fibulin 1 (FBLN1) levels with abdominal aortic calcification (AAC) in patients with maintenance hemodialysis (MHD). Methods General information and biochemical indicators of 74 MHD patients were collected, and they were divided into no to mild AAC group (
n =36) and moderate to severe AAC group (n =38) based on the Abdominal Aortic Calcification Score (AACs). Serum levels of CDC-42, β2-MG and FBLN1 were compared between the two groups, and multivariate Logistic regression analysis was used to explore the risk factors for AAC in MHD patients. Results The dialysis vintage, serum phosphorus, intact parathyroid hormone (iPTH), CDC-42, β2-MG and FBLN1 levels in the moderate to severe AAC group were significantly higher than those in the no to mild AAC group (P < 0.05). AAC in MHD patients was positively correlated with serum phosphorus, iPTH, CDC-42, β2-MG, FBLN1, and dialysis vintage (P < 0.05). High levels of CDC-42, β2-MG and FBLN1 as well as long dialysis vintage were independent risk factors for AAC in MHD patients (P < 0.05). Conclusion Serum CDC-42, β2-MG and FBLN1 levels are positively correlated with AAC in MHD patients. High levels of CDC-42, β2-MG and FBLN1 as well as long dialysis vintage are independent risk factors for AAC in MHD patients.
