Research progress on hypoxia-inducible factor 1α in targeted therapy for hepatocellular carcinoma
- VernacularTitle:缺氧诱导因子1α在肝细胞癌靶点治疗中的研究进展
- Author:
Liheng HUANG
1
;
Hongsheng LIN
;
Zengfu DENG
;
Li YANG
;
Mingfen LI
Author Information
- Publication Type:Research Article
- Keywords: hypoxia-inducible factor; hepatocellular carcinoma; hypoxia-inducible factor 1α
- From: Journal of Clinical Medicine in Practice 2024;28(17):127-130
- CountryChina
- Language:Chinese
- Abstract: Novel therapeutic approaches targeting key genes and regulatory molecules of hepatocellular carcinoma (HCC) have gradually been carried out in clinical practice. Hypoxia-inducible factor (HIF), as a critical factor for hepatocellular carcinoma cells to adapt to the hypoxic microenvironment, mediates changes in the transcription of many genes. HIF has a wide range of target genes and can promote metabolic reprogramming, angiogenesis, invasion and metastasis, and immune escape of cancer cells by regulating various signaling pathways. Hypoxia-inducible factor 1α (HIF-1α), as the main member of the HIF family, can provide new ideas and insights for exploring potential targets for HCC treatment.
