Research progress of circulating tumor DNA in molecular detection of early breast cancer
- VernacularTitle:循环肿瘤DNA在早期乳腺癌分子检测中的研究进展
- Author:
Yu SHI
1
;
Shu XU
Author Information
- Publication Type:Research Article
- Keywords: early breast cancer; circulating tumor DNA; liquid biopsy; biomarkers
- From: Journal of Clinical Medicine in Practice 2024;28(16):136-141
- CountryChina
- Language:Chinese
- Abstract: Breast cancer (BRCA) is the most common malignant tumor in the world and the leading cause of death in female patients. In addition, early detection of BRCA by conventional screening methods (mammography, CT, ultrasound) is limited to a certain extent, and liquid biopsy technology has become increasingly advantageous for the early diagnosis of BRCA patients. Circulating Tumor DNA (ctDNA) is a partially free extracellular DNA present in body fluids. The ctDNA is a new idea for screening novel tumor markers based on liquid biopsy technology and helps in clinical decision-making for early breast cancer. In this paper, we discussed the biological properties of ctDNA, detection methods, and its application in the diagnosis and treatment of early BRCA, and we also look forward to the future research direction of ctDNA.
