Research progress on the protective mechanism of proprotein convertase subtilisin/kexin type 9 inhibitors on vascular endothelium
- VernacularTitle:前蛋白转化酶枯草溶菌素-kexin 9型抑制剂对血管内皮的保护作用机制研究进展
- Author:
Yan FENG
1
;
Wengping LUO
;
Mingming ZHANG
;
Lincong SHE
;
Jiaxin WANG
;
Yongxin SUN
;
Haoqing CHEN
;
Wei ZHANG
Author Information
- Publication Type:Research Article
- Keywords: proprotein convertase subtilisin/kexin type 9 inhibitor; vascular endothelium; pleiotropy; blood lipids; cardiovascular outcomes; inflammation; oxidative stress; autophagy
- From: Journal of Clinical Medicine in Practice 2024;28(15):142-148
- CountryChina
- Language:Chinese
- Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors not only have good lipid-lowering effects, but also have pleiotropic effects such as improving cardiovascular outcomes, relieving anti-inflammation, relieving oxidative stress and improving vascular endothelium. In recent years, the continuous development of PCSK9 inhibitors provides new ideas for the treatment of cardiovascular diseases. This article reviewed the pleiotropic mechanisms of PCSK9 inhibitors, especially on vascular endothelial function.
