In vitro antimicrobial activity of cefditoren against Streptococcus pneumoniae and Haemophilus influenzae clinical isolates.
- Author:
Yee Gyung KWAK
1
;
Eun Ju CHOO
;
Su Jin PARK
;
Jeong Eun LEE
;
Jin Yong JEONG
;
Sang Ho CHOI
;
Nam Joong KIM
;
Yang Soo KIM
;
Jun Hee WOO
;
Jiso RYU
Author Information
1. Division of Infectious Diseases, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
Cefditoren;
Streptococcus pneumoniae;
Haemophilus influenzae
- MeSH:
Agar;
Ampicillin Resistance;
Anti-Bacterial Agents;
Cefixime;
Chungcheongnam-do;
Haemophilus influenzae*;
Haemophilus*;
Humans;
Influenza, Human;
Levofloxacin;
Penicillins;
Pneumonia;
Respiratory Tract Infections;
Streptococcus pneumoniae*;
Streptococcus*;
Tertiary Care Centers
- From:Korean Journal of Medicine
2007;72(1):68-73
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of this study was to determine the in vitro activity of cefditoren, an oral third-generation aminothiazolyl cephalosporin, against Streptococcus pneumoniae and Haemophilus influenzae clinical isolates in a tertiary hospital. METHODS: We have studied the in vitro activities of cefditoren and other oral antibiotics against 120 S. pneumoniae isolates, including 80 penicillin non-susceptible isolates and 80 H. influenzae isolates from clinical specimens of patients at the Asan Medical Center. Minimal inhibitory concentrations (MICs) were determined by the agar dilution method. RESULTS: All S. pneumoniae strains tested were inhibited by 1 g/mL of cefditoren (MIC50/MIC90 0.25/1 microgram/mL; range 0.015~1 microgram/mL). The MICs were lower for penicillin-susceptible S. pneumoniae (MIC90 0.015 g/mL) as compared to penicillin-intermediate resistant (MIC90 0.5 g/mL) or penicillin- resistant strains (MIC90 1 microgram/mL). Cefditoren was active against all tested H. influenzae strains (MIC50/MIC90 0.015/0.03 microgram/mL; range <0.008~0.03 g/mL) and its activity was comparable to levofloxacin and cefixime. CONCLUSIONS: Cefditoren had an excellent activity against S. pneumoniae and H. influenzae irrespective of penicillin or ampicillin resistance, respectively. The results of this study suggest that cefditoren is a good choice of an antibiotic to use for empirical oral treatment of community-acquired respiratory tract infections.
