Research progress on the immunosuppressive mechanism of co-inhibitory receptor T cell immunoglobulin and immunoglobulin and tyrosine-based inhibitory motif domain
- VernacularTitle:共抑制受体T细胞免疫球蛋白和免疫受体酪氨酸抑制基序结构域免疫抑制机制的研究进展
- Author:
Jun HUANG
1
;
Jingjing JIANG
;
Yunli BAO
;
Na LI
;
Ying ZHENG
;
Xiaofeng ZHENG
;
Xiaohui YU
;
Jiucong ZHANG
Author Information
- Publication Type:Research Article
- Keywords: inhibitory receptor; immunoglobulin and immunoglobulin and tyrosine-based inhibitory motif; immunosuppressive mechanism; immune cell
- From: Journal of Clinical Medicine in Practice 2024;28(5):135-138
- CountryChina
- Language:Chinese
- Abstract: The occurrence and development of malignant tumors are closely related to immune checkpoint receptors, and tumor cells can evade immune surveillance by activating the immune checkpoint pathway. T cell immunoglobulin and ITIM domain(TIGIT) is an inhibitory receptor expressed on lymphocytes, which can inhibit the function of natural killer cells(NK) and T cells through a variety of mechanisms, making tumor cells escape from the surveillance of the immune system. This article made a systematic review on the research progress of the immunosuppressive mechanism of TIGIT, and reviewed the research progress of the immunosuppressive mechanism of TIGIT.
