Research progress of protein arginine methyltransferase regulating bone formation and bone healing
- VernacularTitle:蛋白质精氨酸甲基转移酶调控骨形成与骨愈合的研究进展
- Author:
Nan WU
1
;
Miaomiao ZHENG
;
Xinzhe WANG
;
Xiang ZHU
;
Hao TANG
Author Information
- Publication Type:Research Article
- Keywords: arginine methylation; protein arginine methyltransferase; PRMT5; PRMT6; fracture healing; osteoblast; osteoclast
- From: Journal of Clinical Medicine in Practice 2024;28(5):126-129, 134
- CountryChina
- Language:Chinese
- Abstract: Protein arginine methylation is an important post-translational modification (PTM) mediated by protein arginine methyltransferase (PRMTs), which is closely related to the occurrence and development of many diseases. Methylation of arginine is closely related to inflammatory diseases and fracture healing. Decreased expression of PRMTs can lead to delayed or even non-healing of fractures. Both PRMT5 and PRMT6 play an important role in fracture healing and are closely related to the PI3K-AKT and NF-κB pathways. Exploration the relationship between protein arginine methylation and fracture healing can provide a new way to prevent delayed or even non-healing fracture.
