A case report with anti-IgLON family member 5 antibody-related encephalopathy
- VernacularTitle:1例抗IgLON家族蛋白5抗体相关脑病的病例报告
- Author:
Yong PENG
1
;
Cancan MA
;
Lin ZHU
;
Beilei CHEN
;
Mengmei YIN
;
Jian WU
;
Long YU
;
Wenzhe HOU
Author Information
- Publication Type:Research Article
- Keywords: autoimmune encephalitis; anti-IgLON family member 5 antibody-related encephalopathy; cognitive disorder; sleep disorder; epilepsy; immunotherapy
- From: Journal of Clinical Medicine in Practice 2024;28(2):55-59
- CountryChina
- Language:Chinese
- Abstract: This study reported a 50-year-old female patient who was diagnosed with anti-IgLON family member 5 (anti-IgLON5) antibody-related encephalopathy, presented with cognitive and sleep disorders, autonomic dysfunction and seizures, positive serum IgLON5 antibody but negative cerebrospinal fluid IgLON5 antibody, negative human leukocyte antigen (HLA) by genetic testing, and was diagnosed as anti-IgLON5 antibody-related encephalopathy. After hospital admission, the patient was given intravenous methylprednisolone combined with immunoglobulin immunotherapy, donepezil for improvement of cognition, sodium valproate and oxcarbazepine for prevention and treatment of epileptic seizures, and finally her symptoms improved significantly.
