Characteristics of gastric microbiota in <italic>Helicobacter pylori</italic> associated chronic gastritis

Zhanyue NIU; Yanyan SHI; Sizhu LI; Yan XUE

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Characteristics of gastric microbiota in Helicobacter pylori associated chronic gastritis

VernacularTitle:幽门螺杆菌相关慢性胃炎的胃微生态特征分析
Author: Zhanyue NIU ¹ ; Yanyan SHI ; Sizhu LI ; Yan XUE
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1. Department of Gastroenterology, the Third Hospital of Peking University, Beijing, 100191
Publication Type:Research Article
Keywords: Helicobacter pylori; gastric flora; Helicobacter pylori associated chronic gastritis; chronic non-atrophic gastritis; chronic atrophic gastritis; differential analysis
From: Journal of Clinical Medicine in Practice 2024;28(1):56-61
CountryChina
Language:Chinese
Abstract: Objective To investigate the characteristics and differences of gastric flora in chronic non-atrophic gastritis and chronic atrophic gastritis associated with Helicobacter pylori (H. pylori). Methods A prospective study was adopted, and 24 patients with chronic gastritis caused by H. pylori infection were divided into chronic non-atrophic gastritis group (n=18) and chronic atrophic gastritis group (n=6). Characteristics of gastric mucosal flora in both groups were determined, and Alpha and Beta diversity analyses and species correlation analysis were performed. Results The gastric flora in both groups were mainly consisted of Proteobacteria, Bacteroidetes, Firmicutes, Actinobacteria, and Fusobacteria. Significant differences in species diversity and abundance were observed between the two groups (ANOSIM analysis, P=0.046). Fusobacterium (P=0.023), Leptotrichia (P=0.047), Prevotella (P=0.016), Sphingomonas (P=0.042), and Treponema (P=0.006) were significantly enriched in the chronic atrophic gastritis group, and H. pylori showed a decreasing trend (P=0.218). Some species of gastric mucosal flora showed negative correlations with H. pylori, and the number of species negatively associated with H. pylori in the gastric mucosal flora of chronic atrophic gastritis was significantly reduced. Conclusion In the gastric mucosa of chronic atrophic gastritis, the Fusobacterium, Leptotrichia, Prevotella, Sphingomonas, and Treponema are significantly enriched and associated with the progression of chronic gastritis.