Pure Red Cell Aplasia Due to Parvovirus B19 in Renal Transplants.
- Author:
Jeong Ik LEE
1
;
Tae Young KANG
;
Han Pyo CHO
;
Chang Ok YOON
;
Chung Il JUNG
;
Sook Jin LEE
;
Mun Su KANG
;
Chang Hwa LEE
;
Kyoung Won KAHNG
;
Chan Hyun PARK
;
Chong Myung KANG
;
Woong Soo LEE
Author Information
1. Department of Internal Medicine, Hanyang University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
parvovirus B19;
pure red cell aplasia;
renal transplantation
- MeSH:
Adolescent;
Anemia;
Biopsy;
Bone Marrow;
Erythroblasts;
Hematocrit;
Humans;
Immunocompromised Host;
Immunoglobulin M;
Immunoglobulins;
Intranuclear Inclusion Bodies;
Kidney Failure, Chronic;
Kidney Transplantation;
Male;
Parvovirus*;
Polymerase Chain Reaction;
Postoperative Period;
Red-Cell Aplasia, Pure*;
Renal Dialysis;
Reticulocyte Count;
Transplants
- From:Korean Journal of Nephrology
2001;20(4):719-722
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Parvovirus B19 infection is known to cause chronic anemia in immunocompromised hosts, including organ transplant recipients. We report a case of pure red cell aplasia caused by parvovirus B19 in renal transplants. The patient was 16-year-old male who was diagnosed as chronic renal failure 7 years ago and had been on hemodialysis twice a week. He got renal transplantation in June 1999. But anemia was not improved in first postoperative period. On admission hemoglobin was 43.0 g/L, hematocrit was 12.7%. The bone marrow biopsy revealed severe erythroid hypoplasia with giant pronormoblasts. The pronormoblasia with giant prominent intranuclear inclusions, characteristic of parvovirus B19 infection. The parvovirus B19 PCR and anti-parvovirus B19 IgM were positive. The patient was treated with intravenous immunoglobulin and then reticulocyte count was increased 5 days later. Hemoglobin level restored to 104 g/L teo months later.
