Comparison of bone mineral density in premature ovarian failure patients and spontaneous menopausal women.
- Author:
Myung Suk HAN
;
Tae Young HWANG
- Publication Type:Original Article
- Keywords:
premature ovarian failure;
spontaneous menopause;
bone mineral density
- MeSH:
Absorptiometry, Photon;
Bone Density*;
Estradiol;
Estrogens;
Female;
Femur;
Femur Neck;
Humans;
Primary Ovarian Insufficiency*
- From:Korean Journal of Obstetrics and Gynecology
2000;43(11):1979-1982
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: It is widely accepted that the estrogen plays an important role in the maintenance of bone mineral density (BMD). The purpose of this study is to compare the BMD between premature ovarian failure (POF) patients and spontaneous menopausal women, both of which are characterized by estrogen deficiency. METHOD: We compared the BMD of Lumbar 2-4 and Femur neck(right) measured by dual energy X-ray absorptiometry in 17 premature ovarian failure patients and 21 spontaneous menopausal women. RESULTS: POF patients and spontaneous menopausal women showed the BMD of 1.000+/-0.165g/cm2, 1.167+/-0.279g/cm2 at Lumbar 2-4 and 0.793+/-0.132g/cm2, 0.885+/-0.128g/cm2 at Femur neck, respectively. POF patients had lower BMD of Lumbar 2-4 and Femur neck significantly(p<0.05). FSH and estradiol level were not different between the two groups. CONCLUSION: This study demonstrated that the BMD in POF patients was decreased more severely than that of spontaneous menopausal women. Therefore, more preventive measures against bone loss is required in POF patients than spontaneous menopausal women.
