Analgesic Mechanism of Electroacupuncture in an Arthritic Pain Model of Rats: A Neurotransmitter Study.
10.3349/ymj.2011.52.6.1016
- Author:
Young Chul YOO
1
;
Jin Hwan OH
;
Tae Dong KWON
;
Yeong Kyu LEE
;
Sun Joon BAI
Author Information
1. Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea. sjbai1@yuhs.ac
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Arthritis;
electroacupuncture;
neurotransmitter;
pain;
weight-bearing
- MeSH:
Acupuncture Analgesia/*methods;
Adrenergic Antagonists/therapeutic use;
Animals;
Arthritis/chemically induced/drug therapy/physiopathology/*therapy;
Carrageenan/toxicity;
Dopamine Antagonists/therapeutic use;
Electroacupuncture/*methods;
Male;
Neurotransmitter Agents/*metabolism;
Pain/drug therapy/metabolism;
Rats;
Rats, Sprague-Dawley;
Receptors, Adrenergic/metabolism;
Receptors, Dopamine/metabolism;
Receptors, Opioid/antagonists & inhibitors/metabolism;
Receptors, Serotonin/metabolism;
Serotonin Antagonists/therapeutic use
- From:Yonsei Medical Journal
2011;52(6):1016-1021
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We investigated what kinds of neurotransmitters are related with electroacupuncture (EA) analgesia in an arthritic pain model of rats. MATERIALS AND METHODS: One hundred rats were assigned to six groups: control, EA, opioid, adrenergic, serotonin and dopamine group. A standardized model of inflammatory arthritis was produced by injecting 2% carrageenan into the knee joint cavity. EA was applied to an acupoint for 30 min in all groups except fo the control group. In the opioid, adrenergic, serotonin and dopamine groups, each receptor antagonist was injected intraperitoneally to their respective group before initiating EA. RESULTS: In the opioid receptor antagonist group, adrenergic receptor antagonist group, serotonin receptor antagonist group, dopamine receptor antagonist group and the control group weight-bearing force decreased significantly from 30 min to 180 min after EA in comparison with the EA group. CONCLUSION: The analgesic effects of EA are related to opioid, adrenergic, serotonin and dopamine receptors in an arthritic pain model of rats.
