A Case of Basal Cell Carcinoma Treated with Combination of CO2 Laser and 5% Imiquimod Cream.
- Author:
Yong Hyun KWON
1
;
Jae Hui NAM
;
Tae Hwan KIM
;
Ga Young LEE
;
Won Serk KIM
;
Kea Jeung KIM
Author Information
1. Department of Dermatology, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, Korea. gylee0716@hanmail.net
- Publication Type:Case Report
- Keywords:
Basal cell carcinoma;
CO2 laser;
Imiquimod
- MeSH:
Carcinoma, Basal Cell*;
Cryosurgery;
Cytokines;
Fluorouracil;
Humans;
Interferons;
Lasers, Gas*;
Mohs Surgery;
Skin Neoplasms;
Toll-Like Receptor 7
- From:Korean Journal of Dermatology
2007;45(11):1187-1190
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Basal cell carcinoma is the most common skin cancer and surgical treatments like Mohs surgery have been accepted as ideal for it. Although surgical treatments are very effective, non-invasive treatments such as electrocauterization, cryosurgery, CO2 laser and topical 5-fluorouracil cream have been tried because patients need more simple procedures and better cosmetic results. Imiquimod is a Toll-like receptor 7 agonist and which acts as an immune response modifier by inducing several cytokines including interferon. Previously, many reports showed the usefulness of 5% imiquimod cream in treating basal cell carcinoma. However, some local adverse effects, long treatment time and limitation of deep penetration are problems to be resolved. We tried 5% imiquimod cream application after the removal of a visible basal cell carcinoma using CO2 laser, which gave satisfactory results.
