Alkaloids with Acetylcholinesterase Inhibitory Activities from Crinum latifolium L.
- Author:
Vu Thi TRANG
1
;
Pham Van CONG
;
Nguyen Van DAN
;
Nguyen Thi Thu HIEN
;
Do Thanh TUAN
;
Le Tuan ANH
;
Hoang Dac THANG
;
Ngo Viet DUC
;
Hoang Le Tuan ANH
Author Information
- From:Natural Product Sciences 2024;30(4):304-308
- CountryRepublic of Korea
- Language:English
- Abstract: A new crinane-type alkaloid, 6-epihydroxypowelline (1), together with six known alkaloids, lycorine (2), 2-O-acetyllycorine (3), deacetylbowdensine (4), 1-epideacetylbowdensine (5), 8-demethyl-3-oxomaritidine (6), and (-)-marithamine (7) were isolated from the whole parts of the Crinum latifolium L. in Vietnam. The structure identification of all compounds was determined by 1D, 2D-NMR as well as HR-ESI-MS spectroscopic techniques. The absolute configuration of these compounds was established by the ECD data. In addition, in vitro inhibition of acetylcholinesterase (AChE) activities was assessed for all isolated alkaloids. All alkaloids had AChE inhibitory effects, with IC50 values ranging from 32.65 ± 2.72 to 212.76 ± 8.30 µM and compound 3 displayed the strongest inhibition of AChE, with IC50 values of 32.65 ± 2.72 µM (in comparison to the reference drug, galanthamine, which had an IC50 of 2.40 ± 0.45 µM).
