Activities of Serum Lactate Dehydrohenase and Lactate Dehydrogenase Isoenzymes Activities by Small Opacity Groups on Chest Radiographs in Coal Worker's Pneumoconiosis Patients.
- Author:
Ho Deun CHUNG
1
;
Jeong Pyo HONG
Author Information
1. Institute of Occupational Diseases, Korea Labour Welfare Corporation, Korea.
- Publication Type:Original Article
- Keywords:
coal workers' pneumoconiosis;
lactate dehydrogenase;
lactate dehydrogenase isoenzyme activity
- MeSH:
Anthracosis*;
Coal*;
Electrophoresis, Agar Gel;
Humans;
Isoenzymes*;
L-Lactate Dehydrogenase*;
Lactic Acid*;
Pneumoconiosis;
Pyruvic Acid;
Radiography, Thoracic*;
Thorax*
- From:Korean Journal of Occupational and Environmental Medicine
1990;2(2):206-211
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Serum lactate degydrogenase (LD) and LD isoenzyme activities were evaluated in sera from 74 patients of coal workers' pneumoconiosis (CWP) to investigate biochemical changes of these enzyme activities according to radiographical profusions of CWP. Subjects were participated patients in the detailed examination of pneumoconiosis in December 1989. LD activities were evaluated by lactate to pyruvate methods and isoenzyme activities were determined by agarose gel electrophoresis. And small opacity profusions on chest radiographs of subjects were evaluated by radiologist. The results were as follows: 1. LD activities were not significantly different among categories of radiographical profusions. 2. LD4 activities were shown difference significantly among categories of radiographical profusions (category 1: 8.2+/-2.69 U/l, category 2: 10.1+/-3.90, category 3: 10.6+/-2.63; p<0.05). 3. Activities of LD(1), LD(2), LD(3), and LD(5) were not different significantly among categories of radiographical profusions. Conclusionly, serum LD(4) activity seems to be increased by fibroplasia of CWP, but increasing activities of LD4 should not affect serum LD activities significantly.
