The Cytologic Features of Chronic Myelogenous Leukemia and Its Lymphoid Blast Phase in Body Fluid: A Case Report.
- Author:
Soyoung IM
1
;
Changyoung YOO
;
Youn Soo LEE
;
Chang Suk KANG
;
Sang In SIM
;
Kyo Young LEE
Author Information
1. Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. cskang@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Chronic myelogenous leukemia;
Lymphoid blast phase;
Body fluid;
Cytology
- MeSH:
Abdominal Muscles;
Amputation;
Biopsy;
Blast Crisis;
Body Fluids;
Eosinophils;
Erythroblasts;
Femur;
Granulocyte Precursor Cells;
Hematopoietic Stem Cell Transplantation;
Humans;
Immunohistochemistry;
Joints;
Knee;
Knee Joint;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Leukemic Infiltration;
Male;
Megakaryocytes;
Neutrophils;
Peroxidase;
Pleural Effusion
- From:Korean Journal of Pathology
2009;43(2):189-194
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although chronic myelogenous leukemia (CML) may be involved in any part of the body, infiltration of the body fluid has rarely reported in the literature. Here we report on a 35 year-old male patient who was diagnosed chronic myelogenous leukemia ten years previously and he received allogenic hematopoietic stem cell transplantation. He then presented with left knee pain eight years after the initial diagnosis. MRI revealed a soft tissue mass at the distal femur. Cytology of the joint fluid revealed myeloblasts, promyelocytes, eosinophilic myelocytes, band neutrophils, megakaryocytes and orthochromatic erythroblasts, which was all consistent with leukemic infiltration of the knee joint fluid. The immunohistochemistry was positive for CD34, CD117 and myeloperoxidase (MPO). Despite that the patient underwent radiation therapy, MRI revealed growth of the mass, and ten months later, the lymphoid blast phase of CML was confirmed after biopsy. The patient received an above knee amputation. Five months later, multiple masses were revealed on PET-CT at the left iliopsoas muscle, abdominal wall and bones. Bilateral pleural effusion occurred shortly after this. Cytologic evaluation of the pleural fluid also revealed blast-like cells, and histologic evaluation of the abdominal mass confirmed the lymphoid blast phase of CML with positivity for CD3, UCHL-1, CD34 and CD117, but negativity for MPO.
