Association of Interleukin-1alpha-889, beta-31, beta-511 Polymorphism with Risk of Bronchopulmonary Dysplasia.
- Author:
Jeong Hee KANG
1
;
Jung Jin LEE
;
Sung Il CHO
;
Youjin CHOI
;
Heui Seung JO
;
Kyu Hyung LEE
Author Information
- Publication Type:Original Article
- Keywords: Bronchopulmonary dysplasia; Polymorphism; Interleukin-1
- MeSH: Alleles; Birth Weight; Bronchopulmonary Dysplasia*; Discrimination (Psychology); Ductus Arteriosus, Patent; Gestational Age; Humans; Incidence; Infant; Infant Mortality; Infant, Newborn; Infant, Premature; Inflammation; Interleukin-1; Logistic Models; Lung; Medical Records; Pregnancy; Retinopathy of Prematurity; Risk Factors; Survival Rate
- From:Neonatal Medicine 2013;20(4):413-421
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: Although improvements in neonatal care techniques have increased the survival rate of preterm infants, bronchopulmonary dysplasia (BPD) remains an important factor in neonatal mortality and morbidity. BPD is a multifactorial disease associated with genetic and clinical risk factors related to lung development and perinatal inflammation. Interleukin-1 (IL-1) is a crucial cytokine in the early stages of inflammation. In the present study, we aimed to determine the association between the IL-1 polymorphisms, clinical risk factors, and BPD in preterm infants. METHODS: The study was performed who consented infants born at less than 34 weeks' gestation. The alleles of the 3 sites of the IL-1 gene (IL-1alpha-889, IL-1beta-31, and IL-1beta-511) were determined using Taqman(R)-based allelic discrimination assays. Clinical data were reviewed from the medical records. RESULTS: A total of 31 infants with BPD and 73 control infants were enrolled in the study. The gestational age (P=0.001) and birth weight (P=0.001) were lower in the BPD group compared to those in the control group. The incidence of respiratory distress syndrome (RDS; P=0.002), patent ductus arteriosus (P=0.01), and retinopathy of prematurity (P<0.001) was higher in the BPD group compared to that in the control group. The frequency of IL-1alpha-889TT was higher in the BPD group (6.5% vs. 0.0%, P=0.028) compared to that in the control group. The frequencies of IL-1alpha-889T, IL-1beta-31T, and IL-1beta-511T did not differ between the BPD and control groups. In logistic regression analysis, gestational age and RDS were found to be associated with BPD. CONCLUSION: IL-1alpha-889, IL-1beta-31, and IL-1beta-511 polymorphisms are not associated with the development of BPD in preterm infants.
