Efficacy of Erythromycin and Metoclopramide in Neonates with Feeding Intolerance.
- Author:
Kyung Ah SEO
1
;
Na Mi LEE
;
Eung Sang CHOI
;
Byoung Hoon YOO
Author Information
- Publication Type:Original Article
- Keywords: Erythromycin; Feeding intolerance; Metoclopramide; Neonate
- MeSH: Birth Weight; Enteral Nutrition; Erythromycin*; Gestational Age; Humans; Infant; Infant, Newborn*; Infant, Premature; Intensive Care, Neonatal; Metoclopramide*; Parenteral Nutrition; Residual Volume; Retrospective Studies; Tertiary Care Centers
- From:Neonatal Medicine 2013;20(4):462-469
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Feeding intolerance is common in premature infants. It may extend the parenteral nutrition period and increase the risk of complications. We evaluated the efficacy of erythromycin and metoclopramide in neonates with feeding intolerance. METHODS: Between December 2006 to August 2011, 114 neonates with feeding intolerance were divided into two groups treated with either erythromycin or metoclopramide in the neonatal intensive care unit of Chung-ang University Hospital, a tertiary care center. We defined neonates with feeding intolerance as those who either could not be fully fed enterally (120 mL/kg/day) within 7 days or who skipped feeding more than twice per day because the gastric residual volume was >20% of each feed or more than 50% once. The time taken to achieve 50%, 75%, and 100% enteral feeding was estimated retrospectively. RESULTS: The erythromycin group achieved 50% feeding (P=0.047), 75% feeding (P=0.042), and 100% feeding (P=0.039) earlier than the metoclopramide group. The erythromycin group achieved 100% feeding earlier than the metoclopramide group among infants with birth weight > or =1,500 g (P=0.036) and those with gestational age > or =34 weeks (P=0.008). CONCLUSION: Compared with metoclopramide, erythromycin improves feeding in neonates with feeding intolerance, especially in infants with birth weight > or =1,500 g and in those with gestational age > or =34 weeks.
