Glucose-Dependent Insulinotropic Peptide Level Is Associated with the Development of Type 2 Diabetes Mellitus.
10.3803/EnM.2016.31.1.134
- Author:
Sunghwan SUH
1
;
Mi Yeon KIM
;
Soo Kyoung KIM
;
Kyu Yeon HUR
;
Mi Kyoung PARK
;
Duk Kyu KIM
;
Nam H CHO
;
Moon Kyu LEE
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Dong-A Medical Center, Dong-A University College of Medicine, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Gastric inhibitory polypeptide;
Diabetes mellitus, type 2;
Glucagon-like peptide 1
- MeSH:
Case-Control Studies;
Cohort Studies;
Diabetes Mellitus, Type 2*;
Fasting;
Gastric Inhibitory Polypeptide*;
Glucagon-Like Peptide 1;
Glucose;
Incretins;
Multivariate Analysis;
Obesity;
Risk Factors
- From:Endocrinology and Metabolism
2016;31(1):134-141
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Incretin hormone levels as a predictor of type 2 diabetes mellitus have not been fully investigated. Therefore, we measured incretin hormone levels to examine the relationship between circulating incretin hormones, diabetes, and future diabetes development in this study. METHODS: A nested case-control study was conducted in a Korean cohort. The study included the following two groups: the control group (n=149), the incident diabetes group (n=65). Fasting total glucagon-like peptide-1 (GLP-1) and total glucose-dependent insulinotropic peptide (GIP) levels were measured and compared between these groups. RESULTS: Fasting total GIP levels were higher in the incident diabetes group than in the control group (32.64±22.68 pmol/L vs. 25.54±18.37 pmol/L, P=0.034). There was no statistically significant difference in fasting total GLP-1 levels between groups (1.14±1.43 pmol/L vs. 1.39±2.13 pmol/L, P=0.199). In multivariate analysis, fasting total GIP levels were associated with an increased risk of diabetes (odds ratio, 1.005; P=0.012) independent of other risk factors. CONCLUSION: Fasting total GIP levels may be a risk factor for the development of type 2 diabetes mellitus. This association persisted even after adjusting for other metabolic parameters such as elevated fasting glucose, hemoglobin A1c, and obesity in the pre-diabetic period.
