Thyrotoxic Periodic Paralysis and Polymorphisms of the ADRB2, AR, and GABRA3 Genes in Men with Graves Disease.
10.3803/EnM.2016.31.1.142
- Author:
Suyeon PARK
1
;
Tae Yong KIM
;
Soyoung SIM
;
Seonhee LIM
;
Mijin KIM
;
Hyemi KWON
;
Min Ji JEON
;
Won Gu KIM
;
Young Kee SHONG
;
Won Bae KIM
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. tykim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Periodic paralysis-hypokalemic;
Polymorphism;
ADRB2;
Receptors, androgen;
GABRA3
- MeSH:
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Graves Disease*;
Humans;
Hypokalemia;
Male;
Muscle Weakness;
Paralysis*;
Receptors, Androgen;
Thyrotoxicosis
- From:Endocrinology and Metabolism
2016;31(1):142-146
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Thyrotoxic periodic paralysis (TPP) is a rare complication of thyrotoxicosis characterized by acute attacks of muscle weakness and hypokalemia. Recently, variation in several genes was suggested to be associated with TPP. This study evaluated the genetic predisposition to TPP in terms of the β2-adrenergic receptor (ADRB2), androgen receptor (AR), and γ-aminobutyric acid receptor α3 subunit (GABRA3) genes. METHODS: This study enrolled 48 men with Graves disease (GD) and TPP, and 48 GD patients without TPP. We compared the frequencies of candidate polymorphisms between the two groups. RESULTS: The frequency of the Gly16/Gly16 genotype in ADRB2 was not significantly associated with TPP (P=0.32). More CAG repeats (≥26) in the AR gene were not correlated with TPP (odds ratio [OR], 2.46; 95% confidence interval [CI], 0.81 to 8.09; P=0.08). The allele frequency of the TT genotype in the GABRA3 gene was not associated with TPP (OR, 1.83; 95% CI, 0.54 to 6.74; P=0.41). CONCLUSION: The polymorphisms in the ADRB2, AR, and GABRA3 genes could not explain the genetic susceptibility to TPP in Korean men with GD.
