Age- and Sex-Related Volumetric Density Differences in Trabecular and Cortical Bone of the Proximal Femur in Healthy Population
- Author:
María Lorena BRANCE
1
;
Fernando Daniel SARAVÍ
;
Muriel M. HENRÍQUEZ
;
María Silvia LARROUDÉ
;
Jorge E. JACOBO
;
Sebastian Abalo ARAUJO
;
Vanesa LONGOBARDI
;
María Bélen ZANCHETTA
;
María Rosa ULLA
;
Florencia MARTOS
;
Helena SALERNI
;
Beatriz OLIVERI
;
Marina Soledad BONANNO
;
Naraline Luna MENESES
;
Pilar Diaz BACLINI
;
Luis A. RAMÍREZ STIEBEN
;
Silvana Di GREGORIO
;
Lucas R. BRUN
Author Information
- Publication Type:Original Article
- From:Journal of Bone Metabolism 2024;31(4):279-289
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:There are age- and sex-related increases in the prevalence of osteoporosis. Bone densitometry based on dual energy X-ray absorptiometry (DXA) is the gold standard for the assessment of bone mineral density (BMD). Three-dimensional (3D) analysis of the proximal femur (3D-DXA) allows discrimination between cortical and trabecular compartments, and it has shown a good correlation with computed tomography. We aimed to assess age- and sex-related volumetric density differences in trabecular and cortical bone using 3D-DXA and determine the reference intervals for integral volumetric (v)BMD within the Argentine population.
Methods:Healthy female and male adult subjects (N=1,354) from Argentina were included. Hip BMD was measured using DXA, and 3D analysis was performed using 3D-Shaper software. The integral vBMD, cortical surface BMD, and trabecular vBMD (trab vBMD) were measured.
Results:The study population included 73.9% women (N=1,001) and 26.13% men (N=353). We found a significant decrease in integral vBMD between 20 and 90 years in both sexes (women, -23.1%; men, -16.6%). Bone loss indicated in the integral vBMD results was mainly due to a decrease in trabecular bone in both sexes (women, -33.4%; men, -27.7%). The age-related loss of cortical bone density was less and was limited to the female population, without no age-related differences in men. Moreover, 3D-DXA allowed us to propose reference intervals for integral vBMD.
Conclusions:We found age- and sex-related bone loss between 20 and 90 years in an Argentine cohort via integral vBMD measurements using 3D-DXA, mainly due to decreases in trabecular bone in both sexes. The age-related loss of cortical bone density was less and was limited to the female population.
